Design, Synthesis and Antitubercular Activity of 2-(Benzylthio)-1H-benzo[d]imidazoles

Using molecular simplification and hybridization approaches, a series of 2-(benzylthio)-1H-benzo[d]imidazoles was synthesized evaluated as in vitro inhibitors Mycobacterium tuberculosis (M. tuberculosis) growth. Compounds 6p 6z were considered the lead compounds from this molecules, with minimal inhibitory concentration (MIC) values 6.9 3.8 μM against M. H37Rv, respectively. Additionally, leading active multidrug-resistant strains devoid apparent toxicity to Vero HepG2 cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) neutral red assays. Finally, presented good aqueous solubility high plasma stability. These data together indicate that class molecules may furnish new anti-tuberculosis drug candidates for future development.